14731-45-4

Upstream product

• 74-88-4 methyl iodide 
• 14731-25-0 5-(p-methylphenylamino)-1,3,4-thiadiazolium-2-thiolate 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 79010-44-9 1-p-methylphenyl-2,5-dithiohydrazodicarbonamide 
• 79010-48-3 C₁₀H₁₄N₄S₂ 

Downstream Products

• 14731-54-5 (5-methanesulfonyl-[1,3,4]thiadiazol-2-yl)-p-tolyl-amine 

Relevant academic research and scientific papers

Oxidation and Eliminative Cyclisation of S-Alkylisodithiobiureas

Isothiocyanates condense with S-alkylisothiosemicarbazides to yield S-alkylisodithiobiureas.These undergo cyclisation to give 3-amino-5-mercapto-4-substituted-1,2,4-triazoles with the elimination of alkyl mercaptan on heating under neutral conditions, whereas under acidic conditions, by elimination of ammonia 5-alkylmercapto-2-substituted amino-1,3,4-thiadiazoles are formed.Condensation of isothiocyanates with thiosemicarbazides in the presence of alkali affords 1-substituted dithiobiureas.Alkylation of these dithiobiureas with alkyl halides results in the formation of 5-alkylmercapto-2-substituted-amino-1,3,4-thiadiazoles, any intermediateproduct not being isolable.On the other hand, oxidation of 1-substituted dithiobiureas with either hydrogen peroxide or iodine furnishes 2-amino-5-substituted-amino-1,3,4-thiadiazoles.