79010-44-9

Upstream product

• 79-19-6 thiosemicarbazide 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 121359-17-9 N-p-Tolyl-[1,2,4,5]dithiadiazine-3,6-diamine 

Downstream Products

• 14731-49-8 (5-benzylsulfanyl-[1,3,4]thiadiazol-2-yl)-p-tolyl-amine 
• 14731-45-4 (5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-p-tolyl-amine 
• 50621-52-8 (5-Ethylsulfanyl-[1,3,4]thiadiazol-2-yl)-p-tolyl-amine 
• 21123-45-5 2-Amino-5-p-tolylamino-1,3,4-thiadiazole 

Relevant academic research and scientific papers

SYNTHESIS OF SOME 6-ARYLAMINO-3-AMINO-1,2,4,5-DITHIADIAZINES

The synthesis of some new 6-arylamino-3-amino-1,2,4,5-dithiadiazines (IIIa-e) has been achieved by following a novel route.

Oxidation and Eliminative Cyclisation of S-Alkylisodithiobiureas

Isothiocyanates condense with S-alkylisothiosemicarbazides to yield S-alkylisodithiobiureas.These undergo cyclisation to give 3-amino-5-mercapto-4-substituted-1,2,4-triazoles with the elimination of alkyl mercaptan on heating under neutral conditions, whereas under acidic conditions, by elimination of ammonia 5-alkylmercapto-2-substituted amino-1,3,4-thiadiazoles are formed.Condensation of isothiocyanates with thiosemicarbazides in the presence of alkali affords 1-substituted dithiobiureas.Alkylation of these dithiobiureas with alkyl halides results in the formation of 5-alkylmercapto-2-substituted-amino-1,3,4-thiadiazoles, any intermediateproduct not being isolable.On the other hand, oxidation of 1-substituted dithiobiureas with either hydrogen peroxide or iodine furnishes 2-amino-5-substituted-amino-1,3,4-thiadiazoles.