1473360-22-3

Upstream product

• 1473360-15-4 6-azido-2,3,4-tri-O-benzyl-6-deoxy-α-D-mannopyranose-1-O-trichloroacetimidate 
• 100-39-0 benzyl bromide 
• 1473360-05-2 p-tolyl 6-azido-2,3,4-tri-O-acetyl-6-deoxy-1-thio-α-D-mannopyranoside 
• 210170-40-4 1,2,3,4-tetra-O-acetyl-6-azido-6-deoxy-α-D-mannopyranoside 
• 1473360-18-7 3-O-(6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-mannopyranosyl)-sn-glycerol 
• 112-64-1 tetradecanoyl chloride 

Relevant academic research and scientific papers

Synthesis and antiviral evaluation of 6'-acylamido-6'-deoxy-α-d- mannoglycerolipids

Eight new aminomannoglycerolipids (2a-h) with linear, branched, or aromatic acyl chains were synthesized and evaluated for their anti-influenza A virus (IAV) activity. By comparing six mannosyl donors with different protecting and leaving groups, the critical glycosylation reaction employed mannosyl trichloroacetimidate with 2-O-benzoyl protecting group as the donor to give the glycoside with absolute α-anomeric selectivity. The bioactivity results showed that the branched compound 2g could effectively inhibit IAV multiplication in MDCK cells with IC50 69.9 μM.