1473452-75-3Relevant academic research and scientific papers
Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A.,Sheppard, George S.,Wang, Le,Fidanze, Steven D.,Liu, Dachun,Pratt, John K.,Mantei, Robert A.,Wada, Carol K.,Hubbard, Robbert,Shen, Yu,Lin, Xiaoyu,Huang, Xiaoli,Warder, Scott E.,Wilcox, Denise,Li, Leiming,Buchanan, F. Greg,Smithee, Lauren,Albert, Daniel H.,Magoc, Terrance J.,Park, Chang H.,Petros, Andrew M.,Panchal, Sanjay C.,Sun, Chaohong,Kovar, Peter,Soni, Nirupama B.,Elmore, Steven W.,Kati, Warren M.,McDaniel, Keith F.
, p. 2225 - 2233 (2017/04/27)
An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model. Further mo
ISOINDOLONE DERIVATIVES
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, (2013/11/05)
The present invention provides for compounds of formula (I) wherein A, Y, J, R1, R2, and R3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula I.
ISOINDOLONE DERIVATIVES
-
, (2013/11/05)
Provided are compounds of formula (I), wherein A, Y, J, R1, R2, and R3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
