147359-76-0

Basic information

• Product Name: Flibanserin Hydrochloride
• Synonyms: Flibanserin Hydrochloride;Flibanserin HCl
• CAS NO: 147359-76-0
• Molecular Formula: C₂₀H₂₁F₃N₄O*ClH
• Molecular Weight: 426.8630896
• EINECS: 1592732-453-0
• Mol File: 147359-76-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Flibanserin Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Flibanserin Hydrochloride(147359-76-0)
• EPA Substance Registry System: Flibanserin Hydrochloride(147359-76-0)

Safety Data

• Hazardous Substances Data: 147359-76-0(Hazardous Substances Data)

Usage

Uses

Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2).

Upstream product

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• 57061-71-9 1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane 
• 1971858-36-2 1-(prop-1-en-2-yl)-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one 
• 136702-12-0 1-(2-chloro-ethyl)-3-isopropenyl-1,3-dihydro-benzoimidazol-2-one 
• 167933-07-5 flibanserin 
• 22219-23-4 2-ethoxy-1H-benzo[d]imidazole 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 167933-07-5 flibanserin 

Relevant articles and documents

A Facile Route of Synthesis for Making Flibanserin

A novel and efficient route of synthesis for making flibanserin via 2-ethoxy-1H-benzo[d]imidazole (12) was described with excellent yield. This protocol provided a more facile approach to flibanserin.

A preparation method of flibanserin (by machine translation)

The invention discloses a method for preparing of flibanserin, includes the steps of: (1) compound I with dichloroethane reaction to obtain compound II, its without purification, directly with compound III reaction, to obtain the compound IV; (2) compound

NOVEL POLYMORPHS OF FLIBANSERIN HYDROCHLORIDE

The present invention provides novel crystalline anhydrous form II, hemihydrate form III, anhydrous form IV, anhydrous form V, anhydrous form VI, hemihydrate form VII, hemihydrate form VIII, hemihydrate form IX and amorphous form of flibanserin hydrochloride, processes for its preparation and to pharmaceutical compositions containing them.