147383-01-5Relevant academic research and scientific papers
BIOMIMETIC TOTAL SYNTHESIS OF COLNELEIC ACID AND ITS FUNCTION AS A LIPOXYGENASE INHIBITOR
Corey, E. J.,Nagata, Ryu,Wright, Stephen W.
, p. 4917 - 4920 (1987)
A biomimetic synthesis of colneleic acid (2) from 9(S)-hydroperoxy-10(E),12(Z)octadecadienoic acid (1) is reported.The lipoxygenase of potato which converts linoleic acid to 1 was found to be strongly inhibited by acid 2 (Ki=8μM).
