1474024-74-2Relevant academic research and scientific papers
An enantioselective synthesis of voriconazole
Tamura, Keiji,Furutachi, Makoto,Kumagai, Naoya,Shibasaki, Masakatsu
, p. 11396 - 11403 (2013/12/04)
A new seven-step sequence to access voriconazole, a clinically used antifungal agent, was developed. The initial catalytic asymmetric cyanosilylation is the key to constructing the consecutive tetra- and trisubstituted stereogenic centers. The fluoropyrimidine unit frequently triggered unexpected side reactions, but careful amendment of the reaction sequence allowed for the concise enantioselective synthesis.
