1474034-05-3 Usage
Uses
Synthetic triterpenoids, such as RTA 408, are antioxidant inflammation modulator (AIM) that can inhibit tumor cell growth and metastasis via oncogenic signaling pathways. RTA 408 is an anticancer, anti-inflammatory, and antioxidant agent that protects human retinal pigment epithelial cells against H2O2-induced cell injury by activating NF-E2-related factor 2.
Biological Activity
omaveloxolone (rta-408) is a novel synthetic triterpenoid that binds to kelch-like ech-associated protein 1 (keap1) and attenuate nuclear factor erythroid 2-related factor 2 (nrf2) degradation [1].keap1 is involved in proteasomal degradation of nrf2, thereby maintaining low basal levels of nrf2. binding to keap1 and blocking its ability to promote nrf2 degradation increase newly synthesized nrf2 accumulated in the nucleus where nrf2 increases the expression of antioxidant genes and decreases the expression of pro-inflammatory genes [1].in interferon-γ-stimulated raw 264.7 macrophage cells, low concentrations (≤ 25 nm) of rta-408 activated nrf2 and lowered nitric oxide and pro-inflammatory cytokine levels. at higher concentrations, rta-408 inhibited tumor cell growth, with gi50 of 260 ± 74 nm. meanwhile, rta-408 increased caspase activity in tumor cell lines, but not in normal primary human cells.in mice with radiation-induced dermatitis, topical application of rta-408 (0.01%, 0.1% and 1.0%, q.d.) resulted in dose-dependent improvements in the appearance of skin, with 1.0% rta-408 markedly reducing epidermal and collagen thickening, preventing dermal necrosis, and completely alleviating skin ulcers [2].[1]. probst b l, trevino i, mccauley l, et al. rta 408, a novel synthetic triterpenoid with broad anticancer and anti-inflammatory activity. plos one, 2015, 10(4): e0122942.[2]. reisman s a, lee c y, meyer c j, et al. topical application of the synthetic triterpenoid rta 408 protects mice from radiation-induced dermatitis. radiation research, 2014, 181(5): 512-520.
Check Digit Verification of cas no
The CAS Registry Mumber 1474034-05-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,7,4,0,3 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1474034-05:
(9*1)+(8*4)+(7*7)+(6*4)+(5*0)+(4*3)+(3*4)+(2*0)+(1*5)=143
143 % 10 = 3
So 1474034-05-3 is a valid CAS Registry Number.
1474034-05-3Relevant articles and documents
2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF
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, (2014/11/11)
The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.
