147404-82-8

Basic information

• Product Name: (Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate
• Synonyms: 2-Ethoxy-1-[[2'-[[[(ethoxycarbonyl)oxy]amino]iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester
• CAS NO: 147404-82-8
• Molecular Formula: C₂₈H₂₈N₄O₆
• Molecular Weight: 516.54512
• Mol File: 147404-82-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 660.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 4.19±0.10(Predicted)
• CAS DataBase Reference: (Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate(147404-82-8)
• EPA Substance Registry System: (Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate(147404-82-8)

Safety Data

• Hazardous Substances Data: 147404-82-8(Hazardous Substances Data)

Usage

General Description

(Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate is a chemical compound with a complex structure containing a benzo[d]iMidazole core. It is a methyl ester derivative of benzo[d]iMidazole-4-carboxylic acid, with an ethoxy group attached to the methyl carbon. The compound also contains a biphenyl group with an N'-(ethoxycarbonyloxy)carbaMiMidoyl substituent. This chemical may have potential pharmaceutical or research applications due to its complex structure and potential interactions with biological systems. Further research and testing would be needed to fully understand its properties and potential uses.

Upstream product

• 139481-44-0 methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate 
• 1403477-45-1 methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 541-41-3 chloroformic acid ethyl ester 
• 147403-65-4 methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 

Downstream Products

• 147403-03-0 azilsartan 
• 147403-52-9 methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate 
• 1403474-78-1 methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate 
• 147403-52-9 methyl 2-ethoxy-1-[[2’-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 

Relevant articles and documents

Angiotensin II receptor antagonists and its key process for the preparation of intermediates (by machine translation)

This invention has offered a kind of angiotensin II receptor antagonists arab League Qi Shatan and its key intermediate 2-ethoxy-1 - [[ 2 - (N-hydroxy ammonia-methyl-imino) biphenyl-4-yl] - 1H-benzimidazole-7-carboxylic acid methyl ester preparation method, the 1 - [(2-cyano-biphenyl-4-yl) methyl] - 2-ethoxy-benzimidazole-7-carboxylic acid methyl ester with hydroxylamine hydrochloride in water and organic solvent in the mixed solvent prepared by reaction under alkaline conditions 2-ethoxy-1 - [[ 2 - (N-hydroxy ammonia-methyl-imino) biphenyl-4-yl] - 1H-benzimidazole-7-carboxylic acid methyl ester. The 2-ethoxy-1 - [[ 2 - (N-hydroxy ammonia-methyl-imino) biphenyl-4-yl] - 1H-benzimidazole-7-carboxylic acid methyl ester and the halogenated alkane ethyl chloroformate in a solvent, the reaction is under alkaline conditions 2-ethoxy-1 - [[ 2 - [[ ( ethoxycarbonyl ) oxy] amidino] [1,1-biphenyl] - 4-yl] methyl] - 1H-benzimidazole-7-carboxylic acid methyl ester, hydrolysis to obtain arab League Qi Shatan in alkaline conditions. The method of the invention greatly reduces the production cost, improving the yield and purity of product, is suitable for industrial production. (by machine translation)

Aitch sand smooth intermediate and its preparation method (by machine translation)

The invention discloses Aitch sand smooth intermediate and its preparation method. The preparation method comprises the following steps: in the solvent, compound 2B with hydroxylamine mixing, reaction, get compound 3B can be. The invention method for preparing the Aitch of less impurity, short reaction time, the higher process yield, high purity of the product, is suitable for industrial production. (by machine translation)

A METHOD OF PREPARING 2-ETHOXY-1-((2'-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)BIPHENYL- 4-YL)METHYL)-1H-BENZO[D]IMIDAZOLE-7-CARBOXYLATES AND CONVERSION THEREOF TO AZILSARTAN

An improved method of preparing alkyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3- yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylates of formula (I), wherein R is either a branched or unbranched C1-C4 alkyl, ArCH2, Ar2CH, or Ar3C, wherein Ar is a substituted or unsubstituted phenyl, and of conversion thereof to azilsartan of formula (II). This compound is an efficient angiotensin II AT1 receptor antagonist, which is used in the form of the prodrug azilsartan medoxomil of formula (III) in the treatment of hypertension.