1474048-79-7Relevant academic research and scientific papers
Metabolically stable vanillin derivatives for the treatment of hypoxia
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Page/Page column 12; 16; 17, (2021/09/01)
Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
An investigation of structure‐activity relationships of azolylacryloyl derivatives yielded potent and long‐acting hemoglobin modulators for reversing erythrocyte sickling
Abdulmalik, Osheiza,El‐araby, Moustafa E.,Ghatge, Mohini S.,Muhammad, Yosra A.,Omar, Abdelsattar M.,Paredes, Steven D.,Safo, Martin K.
, p. 1 - 21 (2020/11/09)
Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia‐induced HbS polymerization and the subsequent erythrocyte sickling have for s
Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols
Wei, Han-Xun,Lu, Dai,Sun, Vivien,Zhang, Jing,Gu, Yongli,Osenkowski, Pamela,Ye, Wenjuan,Selkoe, Dennis J.,Wolfe, Michael S.,Augelli-Szafran, Corinne E.
, p. 2133 - 2137 (2016/04/20)
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of γ-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.
Weinreb Amide based building block for convenient access to vinyl ketones
Tiwari, Praveen Kumar,Aidhen, Indrapal Singh
supporting information, p. 1777 - 1780 (2013/09/12)
A new strategy for the synthesis of vinyl ketones has been achieved. Hitherto unknown and easily accessible, β-phenylseleno-N-methoxy-N- methylpropanamide, obtained through two simple reactions, served as a building block for convenient access to vinyl ketones. The N-methoxy-N-methyl amide moiety ensured no overaddition of the Grignard reagent and, hence, the excellent formation of β-phenylseleno ketones; oxidative work-up with hydrogen peroxide provided ready access to the vinyl ketones with concomitant loss of phenylselanol. Georg Thieme Verlag Stuttgart · New York.
