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Upstream product

• 13610-02-1 1-phenoxy-2-propyne 
• 1122-91-4 4-bromo-benzaldehyde 
• 873-75-6 4-bromobenzenemethanol 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 107047-10-9 p-bromobenzylazide 
• 108-95-2 phenol 

Relevant academic research and scientific papers

Electrochemical assessment of phenol and triazoles derived from phenol (BPT) on API 5L X52 steel immersed in 1 M HCl

The corrosion inhibition of phenol triazoles was tested with several halogens by means of electrochemical impedance and potentiodynamic polarization. We observed the importance of the 1,2,3-triazole ring in the chemical structure because significant inhibition efficiencies (η) > 90% were achieved at low concentrations with the different halogens. These compounds have a physisorption-type adsorption process, in accordance with the Langmuir model. For long immersion times, the organic inhibitor BPTI showed good corrosion protection during 504 hours of immersion with η > 80%. Furthermore, the hydrodynamic conditions proved that organic molecules experience a desorption process related to the different rotation velocities employed. Finally, it was demonstrated by SEM that the corrosion velocity is diminished when using the BPTI inhibitor at 50 ppm.

1,2,3-Triazole derivatives as antitubercular agents: synthesis, biological evaluation and molecular docking study

Searching for new active molecules against Mycobacterium tuberculosis (MTB) H37Ra, a small focused library of 1,2,3-triazoles has been efficiently prepared via a click chemistry approach. The newly synthesized compounds were tested against drug-sensitive MTB. Several derivatives were found to be promising inhibitors of MTB characterized by lower MIC values (5.8-29.9 μg mL-1). Among all the synthesized 31 compounds, 15e was the most active compound against MTB. Based on the results from the anti-tubercular activity, SAR for the synthesized series has been developed. The active compounds from the anti-tubercular study were further tested for anti-proliferative activity against THP-1, A549 and PANC-1 cell lines using MTT assay and showed no significant cytotoxic activity against these three cell lines except THP-1 at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antioxidant activities with an IC50 range of 10.1-37.3 μg mL-1. The molecular docking study of the synthesized compounds was performed against the DprE1 enzyme of MTB to understand the binding interactions. Moreover, the synthesized compounds were also analysed for ADME properties and all the experimental results promote us to consider this series as a starting point for the development of novel and more potent anti-tubercular agents in the future.

Efficient multicomponent synthesis of mono-, bis-, and tris-1,2,3-triazoles supported by hydroxybenzene scaffolds

A versatile one-pot synthesis of a series of mono-, bis- and tris-1,2,3-triazoles supported by commercially available hydroxybenzene scaffolds has been developed employing click chemistry. The multicomponent copper(I)-catalyzed 1,3-dipolar cycloaddition of sodium azide, propargyl bromide, and a para-substituted benzyl derivative yields N-benzyl-functionalized triazoles featuring several electron-donating or electron-withdrawing groups. Despite the preparation of highly substituted molecules, reaction conditions that provides good yields involved room temperature, times that oscillate between 16 and 24 hours, and catalyst loads ranging from 5-10 mol%. The present methodology could be useful for the building up of multi-triazole libraries easily tunable with donor or attractor functional groups.