147410-09-1Relevant articles and documents
Stereoselective synthesis of 4,5-dihydroxy-D-erythro- and 4,5-dihydroxy-D-threo-L-norvaline from D-ribonolactone
Ariza,Diaz,Font,Ortuno
, p. 1315 - 1326 (2007/10/02)
Nitrogen functions have been introduced stereoselectively at the C-2 position in D-ribonolactone derivatives in order to prepared the title unnatural amino acids. The synthetic strategies lie in the inversion of configuration in S(N)2-type substitution re
An efficient and concise entry to (-)-4,5-dihydroxy-d-threo-l norvaline. Formal synthesis of clavalanine
Ariza, Jesus,Font, Josep,Ortuno, Rosa M.
, p. 1979 - 1982 (2007/10/02)
The title amino acid (2) has been synthesized for the first time in a seven-step sequence from D-ribonolactone, in 20% overall yield. Since the N-carbamoyl derivative of (2) in its y-lactone form has been used to prepare clavalanine, a formal total synthe