147484-88-6

Basic information

• Product Name: N-<1(R)-(benzyloxycarbonyl)ethyl>-α-(S)-(2-phenylethyl)glycine, tert-butyl ester
• Synonyms: N-<1(R)-(benzyloxycarbonyl)ethyl>-α-(S)-(2-phenylethyl)glycine, tert-butyl ester
• CAS NO: 147484-88-6
• Molecular Weight: 397.514
• Mol File: 147484-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-<1(R)-(benzyloxycarbonyl)ethyl>-α-(S)-(2-phenylethyl)glycine, tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-<1(R)-(benzyloxycarbonyl)ethyl>-α-(S)-(2-phenylethyl)glycine, tert-butyl ester(147484-88-6)
• EPA Substance Registry System: N-<1(R)-(benzyloxycarbonyl)ethyl>-α-(S)-(2-phenylethyl)glycine, tert-butyl ester(147484-88-6)

Safety Data

• Hazardous Substances Data: 147484-88-6(Hazardous Substances Data)

Upstream product

• 56777-24-3 benzyl (S)-Lactate 
• 83079-77-0 (S)-α-(2-phenylethyl)glycine, tert-butyl ester 
• 18854-19-8 benzyl pyruvate 

Downstream Products

• 154096-58-9 N-(1(R)-carboxyethyl)-α-(S)-(2-phenylethyl)glycyl-L-leucine, N-phenylamide 

Relevant articles and documents

Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides

An extensive study of the requirements for effective binding of N- carboxyalkyl peptides to human stromelysin, collagenase, and to a lesser extent, gelatinase A has been investigated. These efforts afforded inhibitors generally in the 100-400 nM range for these matrix metalloproteinases. The most significant increase in potency was obtained with the introduction of a β-phenylethyl group at the P1' position, suggesting a small hydrophobic channel into the S1' subsite of stromelysin. One particular compound, N- [1(R)-carboxyethyl]-α(S)-(2-phenylethyl)glycyl-L-leucine, N-phenylamide (79a), is relatively selective for rabbit stromelysin with a K(i) = 6.5 nM and may prove useful for elucidating the role of endogenously-produced stromelysin in lapine models of tissue degradation.