147489-24-5Relevant academic research and scientific papers
Method for preparing 5-substituted chiral hydantoin
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Paragraph 0037; 0038, (2017/02/28)
The invention discloses a method for directly preparing a 5-substituted chiral hydantoin compound by asymmetric catalyzing and hydrogenating of hydantoin-derived exocycloolefin. A chemical structural formula of the 5-substituted chiral hydantoin compound is expressed by a formula (I) shown in the description. A chemical reaction equation is shown in the description, wherein a compound (II) is the hydantoin-derived exocycloolefin; a compound (III) is a catalyst, and the catalyst is a metal compound of chiral diphosphine ligand. Compared with the prior art, the method has the characteristics that the chiral multiplication is realized, the efficiency and selectivity are high, the atom economy is realized, the green and non-pollution effects are realized, the industrialization is easy, and the like.
COMPOUNDS USEFUL AS MODULATORS OF TRPM8
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Paragraph 0760, (2016/03/29)
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
