147526-52-1Relevant academic research and scientific papers
Identification of Sugar Degradation Intermediates in a Metalloporphyrin-mediated DNA Cleavage Resulting from Hydroxylation at C-5'
Pratviel, Genevieve,Pitie, Marguerite,Perigaud, Christian,Gosselin, Gilles,Bernadou, Jean,Meunier, Bernard
, p. 149 - 151 (1993)
Hydroxylation of poly(dA)-poly(dT) at the 5' position of the deoxyribose units by the chemical nuclease Mn-TMPyP-KHSO5 followed by an additional thermal step provides 5'-aldehyde-3',4'-unsaturated nucleosides which can be reduced by sodium borohydride and then hydrogenated with palladium on charcoal giving 2',3'-dideoxyribonucleosides having the natural β or the non-natural α configuration at 4'.
