Identification of Sugar Degradation Intermediates in a Metalloporphyrin-mediated DNA Cleavage Resulting from Hydroxylation at C-5'

DOI: 10.1039/c39930000149

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Journal of the Chemical Society. Chemical communications p. 149 - 151 (1993)

Update date:2022-08-02

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Authors:

Pratviel, Genevieve

Pitie, Marguerite

Perigaud, Christian

Gosselin, Gilles

Bernadou, Jean

Meunier, Bernard

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Article abstract of DOI:10.1039/c39930000149

Hydroxylation of poly(dA)-poly(dT) at the 5' position of the deoxyribose units by the chemical nuclease Mn-TMPyP-KHSO5 followed by an additional thermal step provides 5'-aldehyde-3',4'-unsaturated nucleosides which can be reduced by sodium borohydride and then hydrogenated with palladium on charcoal giving 2',3'-dideoxyribonucleosides having the natural β or the non-natural α configuration at 4'.

Full text of DOI:10.1039/c39930000149

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