147538-91-8Relevant academic research and scientific papers
8-Substituted purine derivatives: a new class of lipid-lowering agents
Vanotti, E.,Bani, M.,Favara, D.,Gobetti, M.,Lombroso, M.,et al.
, p. 287 - 294 (2007/10/02)
A series of purine derivatives have been prepared and their in vivo abilities to lower plasma total cholesterol and triglyceride levels, and to elevate high density lipoprotein (HDL) cholesterol levels in hyperlipemic rats have been tested.Some compounds, among which 8-propylthio>adenosine 31, 8--2-oxopropylthio>adenosine 33 and 8--2-hydrazonecarboxamidepropylthio>adenosine 36 appear to be the most interesting, have been found to have both the desired profile of activity and no hepatotoxicity, when administered po at 50, 100 or 300 mg/kg.Compounds 31, 33 and 36, orally tested at the same doses in the 15-d test, lower triglyceride and VLDL/LDL (very low density lipoprotein / low density lipoprotein) cholesterol levels by 10-33percent and 13-46percent, respectively, and increase HDL-associated cholesterol levels by 10-32percent.These molecules have been chosen for further pharmacological and toxicological evaluations. adenosine / purine / cholesterol / triglyceride / hypolipemic agent
Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them
-
, (2008/06/13)
The novel derivatives of (hetero)aromatic ethers and thioethers represented by the following general formula I:, , (HET)Ar-X-CH2-Y-CH2-O-R (I), , wherein:, (HET)Ar represent a mono-,bi- and tri-cyclic aryl or hetero aryl nucleous possibly substituted, X represents -O- or -S-;, Y represents -CO-, a linear or branched polymethylene having 0 to 8 carbon atoms with the proviso that it is not (CH2)nin which 01), in which R1 is hydrogen or an acyl group deriving from an aliphatic, aromatic or heterocyclic carboxylic acid, provided that R1 is not hydrogen when (HET)Ar represents a guanine, adenine or adenosine group, -C=N-R2, in which R2 is hydrogen or a linear or branched alkyl having 1 to 10 carbon atoms, OH, an alkoxy having 1 to 10 carbon atoms, aryloxy, arylalkoxy, -NH2, -NHCONH2, -NHCSNH2; and R represents a phenyl substituted at para position with a carboxyl or a (C1-C20) alkoxycarbonyl group in which the alkoxy group may be linear or branched, are endowed with antihyperlipidemic activity. There are furthermore described the process for their preparation and the pharmaceutical compositions containing them.
