14757-98-3Relevant articles and documents
Unprecedented single-pot protocol for the synthesis of N1, C6-linked bicyclic 3,4-dihydropyrimidinones via lithiation of Biginelli compounds
Singh, Kamaljit,Singh, Sukhdeep
experimental part, p. 11718 - 11723 (2009/04/11)
4-Aryl/alkyl-6-methyl-3,4-dihydropyrimidin-2(1H)-one ester derivatives readily undergo metalation at the C6 methyl (vinylogous ester) position along with two acidic NHs upon treatment with n-butyllithium at -10 °C. The trianion of DHPMs thus obtained react smoothly with various terminal dibromoalkanes to afford N1, C6-linked bicyclic DHPM derivatives, which represent key structural features of the medicinally potent marine alkaloids such as batzelladine A and crambescin A.