17994-56-8Relevant academic research and scientific papers
Interrogation of 2,2′-Bipyrimidines as Low-Potential Two-Electron Electrolytes
Griffin, Jeremy D.,Pancoast, Adam R.,Sigman, Matthew S.
supporting information, p. 992 - 1004 (2021/01/25)
As utilization of renewable energy sources continues to expand, the need for new grid energy storage technologies such as redox flow batteries (RFBs) will be vital. Ultimately, the energy density of a RFB will be dependent on the redox potentials of the respective electrolytes, their solubility, and the number of electrons stored per molecule. With prior literature reports demonstrating the propensity of nitrogen-containing heterocycles to undergo multielectron reduction at low potentials, we focused on the development of a novel electrolyte scaffold based upon a 2,2′-bipyrimidine skeleton. This scaffold is capable of storing two electrons per molecule while also exhibiting a low (～-2.0 V vs Fc/Fc+) reduction potential. A library of 24 potential bipyrimidine anolytes were synthesized and systematically evaluated to unveil structure-function relationships through computational evaluation. Through analysis of these relationships, it was unveiled that steric interactions disrupting the planarity of the system in the reduced state could be responsible for higher levels of degradation in certain anolytes. The major decomposition pathway was ultimately determined to be protonation of the dianion by solvent, which could be reversed by electrochemical or chemical oxidation. To validate the hypothesis of strain-induced decomposition, two new electrolytes with minimal steric encumbrance were synthesized, evaluated, and found to indeed exhibit higher stability than their sterically hindered counterparts.
Fabrication of porous ultrathin carbon nitride nanosheet catalysts with enhanced photocatalytic activity for N- And O-heterocyclic compound synthesis
Li, Yancong,Ma, Jiliang,Liu, Zhendong,Jin, Dongnv,Jiao, Gaojie,Guo, Yanzhu,Wang, Qiang,Zhou, Jinghui,Sun, Runcang
, p. 365 - 372 (2021/01/11)
A simple and efficient photocatalytic method for the synthesis of dihydropyrimidinones (DHPMs) and their derivatives via porous ultrathin carbon nitride nanosheets (p-CNNs) without solvents was demonstrated. The yields of 3,4-dihydropyrimidin-2(1H)-ones/t
Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates
Kaur, Hardeep,Singh, Lovepreet,Chibale, Kelly,Singh, Kamaljit
, p. 949 - 955 (2019/11/14)
Abstract: Designing small molecule-based new drug candidates through structure modulation of the existing drugs has drawn considerable attention in view of inevitable emergence of resistance. A new series of isoniazid–pyrimidine conjugates were synthesize
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
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Paragraph 0561, (2018/04/20)
The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.
(C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 as a simple and efficient catalyst in Biginelli reaction
Zhang, Xiang,Gu, Xiaoyu,Gao, Yuhua,Nie, Shipeng,Lu, Hongfei
, (2017/03/24)
A highly efficient and facile procedure for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)ones/thiones from the one-pot condensation of aldehyde, β-dicarbonyl compound and urea/thiourea was developed. The methodology is applicable to
Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones
Kumarasamy, Dhanabal,Roy, Biswajit Gopal,Rocha-Pereira, Joana,Neyts, Johan,Nanjappan, Satheeshkumar,Maity, Subhasis,Mookerjee, Musfiqua,Naesens, Lieve
supporting information, p. 139 - 142 (2016/12/27)
A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR,1H NMR,13C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and R
Lipase-Initiated Tandem Biginelli Reactions via in situ-Formed Acetaldehydes in One Pot: Discovery of Single-Ring Deep Blue Luminogens
Zhang, Wei,Wang, Na,Yang, Zeng-Jie,Li, Yan-Rong,Yu, Yuan,Pu, Xue-Mei,Yu, Xiao-Qi
supporting information, p. 3397 - 3406 (2017/10/09)
A facile approach for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones was developed by a tandem multi-component reaction (MCR) in one pot. This approach involves two steps, lipase-catalyzed in situ generation of acetaldehyde and the Biginelli reaction in
Synthesizing method for 3,4-dihydropyrimidinone derivative
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Paragraph 0040; 0041; 0042; 0043; 0044, (2016/10/24)
The invention discloses a synthesizing method for a 3,4-dihydropyrimidinone derivative.The synthesizing method comprises the specific steps that (C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 serves as a catalyst, ethyl alcohol serves as a solvent, a reaction i
Halogenated macroporous sulfonic resins as efficient catalysts for the Biginelli reaction
Shen, Pengfei,Xu, Mancai,Yin, Dulin,Xie, Shaoan,Zhou, Chan,Li, Fada
, p. 18 - 21 (2016/01/25)
A series of halogenated macroporous sulfonic resins A-15-Cl, A-15-Br and A-15-I were synthesized from the precursor Amberlyst 15 by a typical halogenation reaction, and they were evaluated for the catalytic activities of the halogenated macroporous sulfon
Exploiting the Biginelli reaction: Nitrogen-rich pyrimidine-based tercyclic α-helix mimetics
Lim, Zelong,Duggan, Peter J.,Wan, Soo San,Lessene, Guillaume,Meyer, Adam G.,Tuck, Kellie L.
, p. 1151 - 1160 (2016/02/16)
Several rationally designed pyrimidine-based scaffolds intended to mimic the spatial projection of the i, i+3, and i+7 residues of an α-helix and also possess improved aqueous solubility were prepared. A Biginelli-oxidation process was used to form the central pyrimidine ring of these scaffolds, which was subsequently manipulated to form pyrimidine-based tercyclic α-helix mimetics. A pyrimidine-based scaffold designed to mimic the α-helical BH3 domain of the pro-apoptotic Bak protein was also prepared as a putative inhibitor of the Bcl-xL/Bak protein-protein interaction. The pyrimidine-based tercyclic α-helix mimetics, and the putative Bcl-xL inhibitor, were assessed using a luminescence competition assay, however, none displayed inhibitory activity against Bcl-xL or Mcl-1.
