14758-06-6

Upstream product

• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 

Downstream Products

• 125803-41-0 ethyl (+/-)-6-cyano-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate 
• 125803-42-1 ethyl (+/-)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-6-(1H-tetrazol-5-yl)-5-pyrimidinecarboxylate 
• 1443444-56-1 ethyl 1,2,3,4-tetrahydro-2-oxo-4-phenyl-6-[(2-phenylhydrazinylidene)methyl]pyrimidine-5-carboxylate 
• 1443444-50-5 4,6-dihydro-4-phenylpyrimido[4,5-d]pyridazine-2,5-(1H,3H)-dione 

Relevant academic research and scientific papers

Synthesis of 4-Aryl-4,6-dihydropyrimido[4,5-d]pyridazine-2,5(1H,3H)-diones from Biginelli Compounds

Biginelli compounds 1 were first brominated at Me-C(6) with 2,4,4,6-tetrabromocyclohex-2,5-dien-1-one to give Br2CH-C(6) derivatives 2. The hydrolysis of the 6-(dibromomethyl) group of 2c to give the 6-formyl derivative 3c in the presence of an