123237-03-6

Upstream product

• 141-97-9 ethyl acetoacetate 
• 23865-30-7 1,1'-phenylmethanediyl-bis-urea 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 57-13-6 urea 
• 7647-01-0 hydrogenchloride 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 21351-39-3 monocarbamide dihydrogen sulfate 
• 30122-00-0 α-chloro-benzylisocyanate 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 100-51-6 benzyl alcohol 
• 420-04-2 CYANAMID 
• 69207-36-9 ethyl 6-methyl-4-phenylpyrimidin-2(1H)-one-5-carboxylate 

Downstream Products

• 123043-98-1 5-ethoxycarbonyl-3,6-dimethyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 112080-31-6 4-cyclohexyl-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 69207-36-9 ethyl 6-methyl-4-phenylpyrimidin-2(1H)-one-5-carboxylate 
• 593283-24-0 6-methyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide 
• 123043-99-2 5-ethoxycarbonyl-6-methyl-3-acetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 111535-65-0 ethyl 3-carbomethoxy-6-methyl-4-phenyl-3,4-dihydropyrimidine-2(1H)one-5-carboxylate 
• 1012074-54-2 C₁₄H₁₅N₃O₄ 
• 1158806-95-1 C₁₈H₂₃BrN₂O₃ 
• 67092-68-6 ethyl 1-butyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 67092-67-5 ethyl 1-ethyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1158806-97-3 C₁₉H₂₅BrN₂O₃ 
• 1158806-99-5 C₂₀H₂₇BrN₂O₃ 
• 1158806-91-7 C₁₉H₂₆N₂O₃ 
• 1158806-93-9 ethyl 1-decyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of th

Magnesium/methanol: an effective reducing agent for chemoselective reduction of pyrimidine-2(1H)-ones

Magnesium in methanol is an effective reagent for the chemoselective reduction of pyrimidine-2(1H)-ones. Other reducible functionalities such as ester and alkene of enamine ester and uriedo carbonyl remain unaffected. This constitutes the first example of

A Bifunctional Metal/Acid Catalyst for One-pot Multistep Synthesis of Pharmaceuticals

Abstract: One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst. This molecule which has potential interest for the treatment of the obesity in orlistat (Xenical TM) analogue-based therapies has a 3,4-dihydropyrimidin-2(1H)-one (DHPM) scaffold and was obtained by means of a three one-pot process through successive oxidation, cyclocondensation and transesterification reactions. The one-pot strategy was extended to the synthesis of a series of related ester DHPM derivatives.

Magnesium chloride hexahydrate catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)ones under solvent-free conditions

3,4-Dihydropyrimidin-2-(1H)-one were prepared by Biginelli condensation of aldehyde, 1,3-dicarbonyl compound and urea under solvent-free condition at 80°C with magnesium chloride hexahydrate as catalyst.

Synthesis of a 2-Hydrazinyl-1,6-dihydropyrimidine Derivative

Ethyl 4-methyl-6-phenyl-2-[2-(propan-2-ylidene)hydrazinyl]-1,6-dihydropyrimidine-5-carboxylate has been synthesized from ethyl 2-(ethoxymethylidene)-7-methyl-3-oxo-5-phenyl-3,5-dihydro-2H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate.

Decoration of β-CD on Fe3O4@Ag core–shell nanoparticles as a new magnetically recoverable and reusable catalyst for the synthesis of 3,4-dihydropyrimidinones and 2,4-dihydropyrano[2,3-c]pyrazoles in H2O

This report provides a description of the preparation and characterization of a Fe3O4@Ag-β-CD composite as a new magnetically recoverable catalyst for the synthesis of a number of biologically and pharmaceutically significant organic

Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type

A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain.

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by acidic ionic liquids under solvent-free conditions

The acidic ionic liquids were new catalysts for the one-pot Biginelli reaction coupling of aldehyde, 1,3-dicarbonyl compound, and urea to afford the corresponding dihydropyrimidinones in good yields under solvent-free conditions. The catalysts could be re

Manganese-containing periodic mesoporous organosilica with ionic-liquid framework (Mn@PMO-IL): A powerful, durable, and reusable nanocatalyst for the biginelli reaction

The catalytic application of a novel manganese-containing periodic mesoporous organosilica with ionic-liquid framework (Mn@PMO-IL) in the Biginelli reaction was investigated. First, the Mn@PMO-IL nanocatalyst was prepared and characterized by TEM, SEM, X-

Bentonite with high loading of ionic liquid: A potent non-metallic catalyst for the synthesis of dihydropyrimidinones

In attempt to devise an environmentally-benign metal-free catalyst, ionic liquid was supported on bentonite that is a natural clay. To enhance the loading of ionic liquid, bentonite was first functionalized with a dendritic moiety through successive react