14760-49-7 Usage
Uses
Used in Pharmaceutical Industry:
21-dehydrocortisol is used as an intermediate compound for the synthesis of various corticosteroids, which are essential in the treatment of various medical conditions such as inflammation, autoimmune diseases, and adrenal insufficiency. Its role in the pharmaceutical industry is crucial due to its ability to be transformed into other active pharmaceutical ingredients.
Used in Research and Development:
In the field of research and development, 21-dehydrocortisol serves as a valuable compound for studying the structure-activity relationships of corticosteroids. This helps scientists understand the mechanisms of action and develop new drugs with improved efficacy and reduced side effects.
Used in Quality Control and Standardization:
21-dehydrocortisol is also utilized as a reference material in the quality control and standardization of corticosteroid products. It helps ensure the consistency, purity, and potency of these medications, which is vital for their safe and effective use in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 14760-49-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,6 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14760-49:
(7*1)+(6*4)+(5*7)+(4*6)+(3*0)+(2*4)+(1*9)=107
107 % 10 = 7
So 14760-49-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,11,14-16,18,24,26H,3-8,10H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
14760-49-7Relevant academic research and scientific papers
Suzuki,Tada,Matsuda,Yang,Unno
, p. 1481 - 1483 (1993)
Kinetic examination for methoxycarbonylations of the isomeric steroid-17- yl methyl glycolates at C-20 and plots of the amount of each isomer produced by a reaction of their corresponding steroids with cupric acetate in absolute methanol provide a general and facile method for determination of the configuration of the steroid-17-yl methyl glycolates at C-20.
Synthesis of new local anti-inflammatory thiosteroids based on antedrug concept
Milioni, C,Jung, L,Koch, B
, p. 947 - 951 (2007/10/02)
The synthesis and the in vitro pharmacological evaluation of a number of topical corticosteroid derivatives designed on the basis of the antedrug concept are reported.Three series of compounds were synthesized in which sulfur-containing amino acids were incorporated to the steroidal structure in the 21 position.Compounds of series I are diesters of cystine with the 21-hydroxyl groups of the corticosteroids, while series II and III contain 21-amino and 21-thio corticosteroid derivatives, respectively.The new compounds were less potent than the parent corticosteroidsin vitro.The 21-yl--S-acetylamino cysteine 13 was the most interesting compound of the series and is now under further evaluation. topical anti-inflammatory steroids / sulfur amino acids / corticosteroid activity
