147600-75-7

Upstream product

• 151585-62-5 5-Methylene-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester 
• 851-06-9 bis(p-toluenesulfonyl) sulfur diimide 
• 139228-12-9 tert-butyl (3aR,6aS)-5-methylene-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate 

Downstream Products

• 139255-60-0 (3aS,4S,5S,6aR)-5-Hydroxymethyl-4-(toluene-4-sulfonylamino)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester 
• 139228-14-1 (3aS,4S,5S,6aR)-4-(Toluene-4-sulfonylamino)-5-(toluene-4-sulfonyloxymethyl)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester 
• 139255-61-1 N-(3S,4R,5R,7R)-1-Aza-tricyclo[3.3.1.0^3,7]non-4-yl-4-methyl-benzenesulfonamide 
• 139228-24-3 (+/-)-2,5β-methano-1H-3aα,6aα-cyclopenta[c]pyrrol-4α-amine 
• 139255-60-0 (3aS,4S,5R,6aR)-5-Hydroxymethyl-4-(toluene-4-sulfonylamino)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of N-BOC-3-azabicyclo [3.3.0]octan-7-one via reductive Pauson-Khand cyclization and subsequent conversion to a novel diazatricyclic ring system

An intramolecular reductive Pauson-Khand reaction of the hexacarbonyldicobalt complex of N-(tert-butyloxycarbonyl)allylpropargylamine under dry-state adsorption conditions directly afforded the saturated N-BOC-3-azabicyclo[3.3.0]octan-7-one when the react

USE OF ATOM-TRANSFER RADICAL CYCLIZATIONS AS AN EFFICIENT ENTRY INTO A NEW "SEROTONERGIC" AZANORADAMANTANE

A route to azanoradamantanes is described which makes use of an atom-transfer radical cyclization to afford 3-azabicycloocatanes 3A and 3B.Subsequent elaboration of exo-allylamine functionality, followed by cyclization of the endo-hydroxymethyl intermediate 9, affords the new azanoradamantanes 11 and 4.This new azatricyclic system is useful for producing serotonin 5-HT3 antagonists and 5-HT4 agonists. Key words: Azanoradamantane; 3-azabicyclooctane; serotonin