1476048-27-7Relevant academic research and scientific papers
Diversity-oriented approach to novel spirocycles via 1,2,4,5-tetrakis(bromomethyl)benzene under operationally simple reaction conditions
Kotha, Sambasivarao,Ali, Rashid
, p. 6944 - 6955 (2015)
Here, we have established a simple and an efficient methodology for the synthesis of spirocyclic α-amino acids as well as spirosulfones starting with readily available active methylene compounds (AMCs). The key di-bromo building blocks were assembled by reacting various active methylene compounds with 1,2,4,5-tetrakis(bromomethyl)benzene in one step. We have also expanded this strategy to generate a variety of bis-spirocycles by treating the di-bromo intermediates with different AMCs under operationally simple reaction conditions.
