1476048-33-5Relevant academic research and scientific papers
Design and synthesis of angularly annulated spirocyclics via enyne metathesis and the Diels-Alder reaction as key steps
Kotha, Sambasivarao,Ali, Rashid,Tiwari, Arti
, p. 2471 - 2480 (2014)
We have developed a simple and an efficient route to a range of angularly fused spirocycles by the application of enyne metathesis and the Diels-Alder reaction as key steps. The enyne metathesis protocol has been further extended to the dibenzylation of indane-1,3-dione by using cross-enyne metathesis in the presence of hexa-1,5-diene with the aid of Grubbs' 1st generation catalyst followed by an aromatization sequence with DDQ. Georg Thieme Verlag Stuttgart New York.
Design and Synthesis of Angularly Annulated Spirocyclics via Enyne Metathesis and the Diels-Alder Reaction as Key Steps
Kotha, Sambasivarao,Ali, Rashid,Tiwari, Arti
, p. 2471 - 2480 (2015/12/26)
We have developed a simple and an efficient route to a range of angularly fused spirocycles by the application of enyne metathesis and the Diels-Alder reaction as key steps. The enyne metathesis protocol has been further extended to the dibenzylation of indane-1,3-dione by using cross-enyne metathesis in the presence of hexa-1,5-diene with the aid of Grubbs' 1st generation catalyst followed by an aromatization sequence with DDQ.
Diversity-oriented approach to novel spirocyclics via enyne metathesis, diels-alder reaction, and a [2+2+2] cycloaddition as key steps
Kotha, Sambasivarao,Ali, Rashid,Tiwari, Arti
, p. 1921 - 1926 (2013/09/24)
A simple protocol for the synthesis of indane-based spirocyclics has been developed via enyne metathesis, Diels-Alder reaction, and a [2+2+2] cycloaddition as key steps starting from indane-1,3-dione. The key diene building block was assembled by enyne metathesis. In this sequence, rongalite is used as a green reagent to prepare the sultine intermediate, which is a useful precursor to generate the transient diene.
