1476064-47-7

Upstream product

• 10297-06-0 1-chloro-5-hexyne 
• 1159265-95-8 2-deoxy-2-fluoro-β-D-glucopyranosyl azide 
• 1476064-49-9 2-({[5-(2,6-dimethoxyphenyl)-1-(4-{[{3-[hex-5-yn-1-yl(methyl)amino]propyl}(methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid 
• 1476064-43-3 N,N'-dimethyl-N-[6-(triisopropylsilyl)hex-5-ynyl]propane-1,3-diamine 
• 1476064-44-4 2-({[5-(2,6-dimethoxyphenyl)-1-(2-isopropyl-4-{[methyl(3-{methyl[6-(triisopropylsilyl)hex-5-yn-1-yl]amino}propyl)amino]carbonyl}phenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and evaluation of a 18F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors

Aiming to image NTS1 overexpressing tumors, the diarylpyrazole glycoconjugate 8, derived from the potent NTS1 antagonist SR142948A, was synthesized taking advantage of the palladium-catalyzed aminocarbonylation reaction. The glycoconjugate 8 displayed excellent affinity and selectivity toward NTS1. Radiosynthesis proceeded straightforwardly, obtaining [ 18F]8 with excellent stability and highly beneficial biodistribution in vivo as demonstrated by PET imaging in HT29 tumor-bearing nude mice. Thus, the tracer [18F]8 represents a highly promising candidate for PET imaging of NTS1-positive tumors.