1476070-64-0

Basic information

• Product Name: 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetylglycine2-(p-nitrophenyl)ethyl ester
• Synonyms: 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetylglycine2-(p-nitrophenyl)ethyl ester
• CAS NO: 1476070-64-0
• Molecular Weight: 632.571
• Mol File: 1476070-64-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetylglycine2-(p-nitrophenyl)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetylglycine2-(p-nitrophenyl)ethyl ester(1476070-64-0)
• EPA Substance Registry System: 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetylglycine2-(p-nitrophenyl)ethyl ester(1476070-64-0)

Safety Data

• Hazardous Substances Data: 1476070-64-0(Hazardous Substances Data)

Upstream product

• 1476070-51-5 glycine 2-(p-nitrophenyl)ethyl ester hydrochloride 
• 1476070-49-1 C₁₅H₂₀N₂O₆ 
• 58479-71-3 5-hydroxymethyl-2',3'-O-isopropylidene-2-thiouridine 
• 1476070-58-2 C₂₃H₂₈N₄O₉S 
• 407-25-0 trifluoroacetic anhydride 
• 100-27-6 2-(4-nitrophenyl)ethanol 

Downstream Products

• 1476070-70-8 N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetylglycine2-(p-nitrophenyl)ethyl ester 

Relevant articles and documents

Mt-tRNA components: Synthesis of (2-Thio)uridines modified with blocked glycine/taurine moieties at C-5,1

In this paper, we discuss the usefulness of reductive amination of 5-formyl-2′,3′-O-isopropylidene(-2-thio)uridine with glycine or taurine esters in the presence of sodium triacetoxyborohydride (NaBH(OAc) 3) for the synthesis of the native mitochondrial (mt) tRNA components 5-carboxymethylaminomethyl(-2-thio)uridine (cmnm5(s2)U) and 5-taurinomethyl(-2-thio)uridine (τm5(s2)U) with a blocked amino acid function. 2-(Trimethylsilyl)ethyl and 2-(p-nitrophenyl)ethyl esters of glycine and 2-(2,4,5-trifluorophenyl)ethyl ester of taurine were selected as protection of carboxylic and sulfonic acid residues, respectively. The first synthesis of 5-formyl-2′,3′-O-isopropylidene-2-thiouridine is also reported.