147609-44-7

Basic information

• Product Name: (1R,2R)-2-(chloromethyl)-1-(dicyclohexylphosphinyl)cyclopentane
• CAS NO: 147609-44-7
• Molecular Weight: 330.878
• Mol File: 147609-44-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R)-2-(chloromethyl)-1-(dicyclohexylphosphinyl)cyclopentane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-(chloromethyl)-1-(dicyclohexylphosphinyl)cyclopentane(147609-44-7)
• EPA Substance Registry System: (1R,2R)-2-(chloromethyl)-1-(dicyclohexylphosphinyl)cyclopentane(147609-44-7)

Safety Data

• Hazardous Substances Data: 147609-44-7(Hazardous Substances Data)

Upstream product

• 147609-42-5 (1R,2R)-1-(diphenylphosphinyl)-2-(hydroxymethyl)cyclopentane 
• 186249-59-2 (1S,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-cyclopentanol 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 122331-03-7 ethyl (1S,2S)-2-hydroxycyclopentanecarboxylate 
• 133320-04-4 (1S,2R)-2-(hydroxymethyl)cyclopentan-1-ol 
• 147609-43-6 (1R,2R)-1-(dicyclohexylphosphinyl)-2-(hydroxymethyl)cyclopentane 

Downstream Products

• 147609-45-8 (1R,2R)-1-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)methyl>cyclopentane 
• 1026124-96-8 [(1R,2R)-2-(Dicyclohexyl-phosphinoyl)-cyclopentylmethyl]-diphenyl-phosphane 

Relevant articles and documents

Development of new 6-membered chelating chiral bisphosphine ligands for rhodium-catalyzed asymmetric hydrogenation

A new chiral 1,3-bisphosphine, (1R,2R)-1-diphenylphosphino-2-(diphenylphosphinomethyl)cyclopentane, which was designed to form the favorable skew conformation of the six-membered chelate with rhodium, was developed. Its rhodium complex was found to be one of the most efficient catalysts known for asymmetric hydrogenation of amino acid precursors. Further improvement of this ligand was also attempted for catalytic asymmetric hydrogenation of prochiral ketones to clarify the enantioselective mechanism.