147622-60-4Relevant articles and documents
Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (Ca Pkc1)
Hung, Dao Viet,Vu, Tran Khac
, (2021/08/12)
The protein kinase Pkc1 of Candida albicans (CaPkc1), one of the key proteins involved in MAPK pathway, is described as a regulator of cell wall integrity during growth, morphogenesis, and response to cell wall stress. The (-)-cercosporamide is an antifun
Elaboration of simplified vinca alkaloids and phomopsin hybrids
Ngo, Quoc Anh,Roussi, Fanny,Thoret, Sylviane,Gueritte, Francoise
experimental part, p. 284 - 294 (2010/12/19)
Nine simplified vinca alkaloids and phomospin A hybrids, in which vindoline moiety has been replaced by a simpler scaffold, have been elaborated to evaluate their activity on the inhibition of tubulin polymerization. This article deals with the synthesis of various simplified vinca alkaloids, using a stereoselective coupling of catharantine with reactive aromatic compounds and methanol as well as their subsequent condensation with a large peptide chain mimicking those of phomopsin A. Biological evaluation and molecular modeling studies are also reported.
A Formal Synthesis of Aflatoxin B2
Weeratunga, Gamini,Horne, Stephen,Rodrigo, Russell
, p. 721 - 722 (2007/10/02)
A brief synthesis of a ring A differentiated tetrahydrofurobenzofuran intermediate previously converted into Aflatoxin B2 is described.
