147637-69-2

Upstream product

• 22288-66-0 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione 
• 100-52-7 benzaldehyde 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1449485-46-4 3-(3-nitrophenyl)-4-phenyl-4H-spiro[isoxazole-5,3'-pyrido[1,2-a]pyrimidine]-2',4'-dione 
• 1449485-47-5 3-(4-chlorophenyl)-4-phenyl-4H-spiro[isoxazole-5,3'-pyrido[1,2-a]pyrimidine]-2',4'-dione 
• 1449485-52-2 3-phenyl-3H-isoxazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(3aH)-one 
• 1449485-55-5 3-phenyl-3,3a-dihydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(2H)-one 

Relevant academic research and scientific papers

Synthesis, characterization and biological activity of new cyclization products of 3-(4-substituted benzylidene)-2H-pyrido[1,2-a]pyrimidine 2,4-(3H)-diones

A method is presented for the synthesis of 4-(substituted phenyl)-3-(3-substituted phenyl)4H-spiro[isoxazole-5,3′-pyrido[1,2-a] pyrimidine]-2′,4′-dione (3), 3-(4-substituted phenyl)-3H- isoxazole[3, 4-d]pyrido[1,2-a]pyrimidin-4-(3aH)-one (4) and 3-(4-substituted phenyl) 3,3a-dihydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4-(2H)-one (5) which consists of the conversion of 2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione (1) to chalcones (2) and their 1,3-dipolar cycloaddition with appropriate aldoximes to give spiro compounds and heterocyclization using amines to yield isoxazolines and pyrazolines. All the compounds were screened for their antimicrobial and antitubercular activity.