1476768-79-2Relevant academic research and scientific papers
A two-step synthesis of selected 1,2,3,4-tetrahydroquinoxaline derivatives from N -aryl-2-nitrosoanilines and arylidenecyanoacetic esters
Królikiewicz, Magdalena,B?aziak, Kacper,Danikiewicz, Witold,Wróbel, Zbigniew
supporting information, p. 1945 - 1948 (2013/09/24)
Reaction of N-aryl-2-nitrosoanilines with alkyl arylidenecyanoacetates in the presence of Et3N in MeCN leads to substituted 1,2,3,4-tetrahydroquinoxaline derivatives in reasonable yields. The reaction comprises nucleophilic addition of the nitrosoaniline to the Michael acceptor followed by cyclization involving the nitroso group. Since the reactive nitrogen groups in N-aryl-2-nitrosoanilines are of opposite character the reaction is regioselective and additionally it was found to be diastereoselective.
