147677-92-7Relevant academic research and scientific papers
On the alkylation behavior of 2-(phenylseleno) nitriles
Jahn,Curran
, p. 565 - 567 (2007/10/03)
Alkylation of (phenylseleno)acetonitrile 1 with alkyl iodides provides preferentially monoalkylated derivatives 3 with LiHMDS as base. 2-(Phenylseleno) nitrites 3 yield dialkylated derivatives in excellent yields.
Synthesis of α-Arylated Phenylsulfonylacetonitriles. A Useful Precursor for Substituted α-Arylalkanoic Acid and Their Derivatives
Suzuki, Hitomi,Yi, Qui,Inoue, Junko,Kusume, Kumiko,Ogawa, Takuji
, p. 887 - 890 (2007/10/02)
Copper(I) iodide-catalyzed reaction of aryl iodides with anion derived from phenylsulfonylacetonitrile in hot hexamethylphosphoric triamide affords α-arylated nitriles in good to moderate yields.Further alkylation of these nitriles followed by reductive removal of sulfonyl group provides a simple route to α-arylalkanenitriles.
