(S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate is a complex organic compound that serves as a crucial intermediate in the synthesis of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor. (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate plays a significant role in the development of targeted therapies for cancer treatment, particularly for tumors with mutations in the BRCA-1 and BRCA-2 genes.
1476776-84-7
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Basic information
- Product Name: (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
- Synonyms: (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
- CAS NO:1476776-84-7
- Molecular Formula:
- Molecular Weight: 476.619
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 571.7±50.0 °C(Predicted)
- Flash Point: N/A
- Appearance: N/A
- Density: 1.17±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate(CAS DataBase Reference)
- NIST Chemistry Reference: (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate(1476776-84-7)
- EPA Substance Registry System: (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate(1476776-84-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1476776-84-7(Hazardous Substances Data)
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1476776-84-7 Usage
Uses
Used in Pharmaceutical Industry:(S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate is used as an intermediate in the synthesis of Niraparib (N481400) for the development of targeted cancer therapies. Its application is primarily due to its role in the creation of a PARP inhibitor that is effective against BRCA-1 and -2 mutant tumors, offering a promising treatment option for patients with these specific genetic mutations.
As a key component in the synthesis of Niraparib, (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate contributes to the advancement of cancer research and the development of personalized medicine approaches. The use of PARP inhibitors like Niraparib has shown potential in improving the survival rates and quality of life for patients with BRCA-1 and -2 related cancers, making (S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate an essential compound in the pharmaceutical industry for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 1476776-84-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,7,6,7,7 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.Calculate Digit Verification of CAS Registry Number 1476776-84:
(9*1)+(8*4)+(7*7)+(6*6)+(5*7)+(4*7)+(3*6)+(2*8)+(1*4)=227
227 % 10 = 7
So 1476776-84-7 is a valid CAS Registry Number.
1476776-84-7Upstream product
1476776-84-7Downstream Products
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(S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
