147696-46-6Relevant articles and documents
Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase
Bebernitz, Gregory R.,Aicher, Thomas D.,Stanton, James L.,Gao, Jiaping,Shetty, Suraj S.,Knorr, Douglas C.,Strohschein, Robert J.,Tan, Jennifer,Brand, Leonard J.,Liu, Charles,Wang, Wei H.,Vinluan, Christine C.,Kaplan, Emma L.,Dragland, Carol J.,DelGrande, Dominick,Islam, Amin,Lozito, Robert J.,Liu, Xilin,Maniara, Wieslawa M.,Mann, William R.
, p. 2248 - 2257 (2007/10/03)
The optimization of a series of anilide derivatives of (R)-3,3,3- trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3- trifluoro-2-hydroxy-2-methylpropanamide 1 (IC
(R)-3,3,3-trifluoro-2-hydroxy-2-methyl- propionamides are orally active inhibitors of pyruvate dehydrogenase kinase [2]
Aicher, Thomas D.,Anderson, Robert C.,Bebernitz, Gregory R.,Coppola, Gary M.,Jewell, Charles F.,Knorr, Douglas C.,Liu, Charles,Sperbeck, Donald M.,Brand, Leonard J.,Strohschein, Robert J.,Gao, Jiaping,Vinluan, Christine C.,Shetty, Suraj S.,Dragland, Carol,Kaplan, Emma L.,DelGrande, Dominick,Islam, Amin,Liu, Xilin,Lozito, Robert J.,Maniara, Wieslawa M.,Walter, R. Erik,Mann, William R.
, p. 2741 - 2746 (2007/10/03)
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Therapeutic amides
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, (2008/06/13)
Amides having formula I: STR1 wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.
