374-35-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs.
Used in Agrochemical Industry:
2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID is used as an intermediate in the synthesis of agrochemicals, playing a role in the production of substances that help protect crops and enhance agricultural productivity.

Upstream product

• 337-16-6 2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester 
• 693287-30-8 (R)-2,3-epoxy-2-(trifluoromethyl)propionic acid 
• 114645-34-0 (R,S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide 
• 335-08-0 1,1,1-trifluoropropan-2-one cyanohydrine 
• 422-25-3 β,β,β-trifluoro-α-hydroxy-thioisobutyric acid amide 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 143-33-9 sodium cyanide 
• 56135-02-5 α-methoxy-α-trifluoromethylpropionic acid 
• 857934-65-7 3,3,3-trifluoro-2-methoxy-2-methyl methyl propionate 
• 10041-92-6 ethyl 2-acetoxy-2-(trifluoromethyl)propionate 

Downstream Products

• 243982-42-5 N-cyclohexyl-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide 
• 329901-37-3 (R)-N-(4-[Anilinosulphonyl]-2,5-dimethoxyphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 
• 329901-38-4 (R)-N-(2,5-Dimethoxy-4-[dimethylaminosulphonyl]phenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 
• 242139-87-3 (R)-N-[2-chloro-4-iodophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329926-82-1 (R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329794-58-3 (R)-[5-(4-methylsulphanylphenylsulphanyl)-1-(3,3,3-trifluoro-2-hydroxy-2-methylpropionyl)indoline] 
• 1360607-89-1 4-((3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)thio)N,N-dimethylbenzamide 
• 329925-77-1 (2R)-N-[2-chloro-4-(ethylsulfonyl)-3-fluorophenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 
• 374-35-6 (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 
• 24435-45-8 (S)-2-trifluoromethyllactic acid 
• 72114-92-2 ZM 130352 
• 131131-30-1 N-phenyl-α-trifluoromethyllactyl amide 
• 337-16-6 2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester 
• 107018-39-3 2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid ethyl ester 

Relevant academic research and scientific papers

α-Methoxy-α-trifluoromethylpropionic Acid (MTPr). A New Chiral Derivatizing Reagent for GC Separation of Enantiomeric Amino Acids

A title homochiral acid has been synthesized and shown to be an efficient chiral derivatizing reagent for capillary gas chromatographic separation of emnantiomeric amino acids at considerably low column temperature.

Method for synthesizing 2-hydroxy-2-(fluoro-containing methyl) propionic acid

The invention provides a method for synthesizing 2-hydroxy-2-(fluoro-containing methyl) propionic acid. The method takes 2-methylacetoacetic ester as a starting raw material, and the 2-hydroxy-2-(fluoro-containing methyl) propionic acid is obtained after an alpha-substitution reaction, a Baeyer-Villiger oxidation reaction, saponification, and an acidification reaction. The raw materials of the reaction route are easily available, the reaction conditions are safe and mild, and the method is suitable for industrial production.

2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations

It has been postulated that one of the biggest impediments to a successful chemotherapy is the phenomena of multidrug resistance (MDR) in cancer cells. One of the main mechanisms of MDR is overexpression of the ATP-binding cassette (ABC) transporters in c

Efficient preparation of both enantiomers of 3,3,3-trifluoro-2-hydroxy-2- methylpropanoic acid catalyzed by Shinella sp. R-6 and Arthrobacter sp. S-2

Several microorganisms that can enantioselectively hydrolyze 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide have been isolated from soil samples. These strains were capable of growing in a medium containing 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide as the sole nitrogen source. Among them, Shinella sp. R-6 was identified as a strain capable of exhibiting R-selective hydrolysis activity, while Arthrobacter sp. S-2 was capable of exhibiting S-selective hydrolysis activity. The preparation of both enantiomers of 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid via the two-step whole-cell reaction was investigated using these two strains.

Chirality-dependent sublimation of α-(trifluoromethyl)-lactic acid: Relative vapor pressures of racemic, eutectic, and enantiomerically pure forms, and vibrational spectroscopy of isolated (S,S) and (S,R) dimers

A mass-spectrometric determination of the sublimation pressure diagram of α-(trifluoromethyl)-lactic acid as a function of its enantiomeric composition at 293 K shows that the racemic crystals have a 38 ± 15 % higher volatility than the enantiomerically p

Method for controlled polymerization of o-carboxy anhydrides derived from alpha-hydroxy acids

The invention concerns a method for preparing poly(-hydroxy acids), the polymerization reaction being performed in controlled manner in the presence of a catalytic system including a base, said base being a 5- or 6-membered aromatic heterocycle comprising

Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1

2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.

Synthetic application of 3,3-dichloro-1, 1, 1-trifluoroacetone (DCTFA) and 3,3,3-trichloro-1, 1, 1-trifluoroacetone (TCTFA) for trifluorolactic acid derivatives

Synthetic application of 3,3-dichloro-1,1,1-trifluoroacetone (DCTFA) and 3,3,3-trichloro-1,1,1-trifluoroacetone (TCTFA) for industrially important trifluorolactic acid derivatives is described. Trifluorolactic acid was obtained by hydrolysis of DCTFA unde

Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity

A compound of formula (I) wherein: n is 1 or 2; R 1 is chloro, fluoro, bromo, methyl or methoxy; R 2 is as defined within; R 3 is as defined within; and R 4 is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed. STR1

Optically active fluorine-containing compounds and processes for their production

An optically active fluorine-containing compound represented by the following formula (1) or (2) wherein A is an oxygen atom, a sulfur atom or an NH group, and R1 selected from a variety of organic group, is used in the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid.