14770-98-0

Usage

Preparation

Preparation by Fries rearrangement of 2,3-dimethylphenyl benzoate in the presence of aluminium chloride at 180° for 10 min (60%).

Upstream product

• 98-88-4 benzoyl chloride 
• 59014-76-5 4-Methyl-benzoic acid 2,3-dimethyl-phenyl ester 

Downstream Products

• 116544-73-1 6,7-Dimethyl-3-phenyl-2-p-tolyl-benzofuran 
• 116544-67-3 (6-Benzoyl-2,3-dimethyl-phenoxy)-p-tolyl-acetic acid 
• 116544-57-1 (6-Benzoyl-2,3-dimethyl-phenoxy)-p-tolyl-acetic acid ethyl ester 

Relevant academic research and scientific papers

Cyclodeshydratation d'aryloxy-2 diaryl-1,2 ethanones en diaryl-2,3 benzofurannes. Influence de la substitution sur la competition entre deux chemins reactionnels

Many of the methods for synthesizing derivatives of 2,3-diaryl benzofurans imply cyclodehydration of 1,2-diaryl 2-aryloxyethanones, leading often to a mixture of two isomers which differ by the presence of the aryl substituent at positions C-2 or C-3 of benzofuran.This isomerisation is explained by a competition between two possible mechanisms.Either a direct electrophilic substitution or the intermediate formation of an α-acylcarbenium ion.This study deals with the competition as determined by the substitution of aryl groups in the initial substrate.Each 2,3-diarylbenzofuran was synthesized previously using an unambiguous method.