147722-52-9

Upstream product

• 536-74-3 phenylacetylene 
• 169274-98-0 (+)-(1R,2R,3'R)-1-Phenyl-2-(1'-phenylhept-1'-in-3'-ylamino)propan-1,3-diol 
• 169274-93-5 ((4R,5R)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-[3-phenyl-prop-2-yn-(E)-ylidene]-amine 
• 2579-22-8 Phenylpropargyl aldehyde 
• 479543-21-0 N,N-diallyl-1-phenyl-1-heptyn-3-amine 
• 169208-90-6 (+)-(R)-N-(1-Phenylhept-1-in-3-yl)formamid 

Relevant academic research and scientific papers

Synthesis of enantiomerically enriched propargylamines by copper-catalyzed addition of alkynes to enamines

The first copper(I) bromide/Quinap-catalyzed synthesis of enantiomerically enriched propargylamines by addition of alkynes to enamines is reported. Various functionalized terminal alkynes add smoothly to N-protected enamines to afford the corresponding am

Enantioselective synthesis of propargylamines by copper-catalyzed addition of alkynes to enamines

Enantiomerically enriched, functionalized, and protected propargylamines are obtained under mild conditions in a new copper(I)/Quinap-catalyzed addition reaction of alkynes to enamines (see scheme).

Enantioselektive Synthese von Allyl-, Propargyl- und 4-En-2-inyl-aminen durch 1,2-Addition von Organocer-Reagenzien an chirale Aldimine

(E)- and (Z)-Allyl-, propargyl, and 4-en-2-ynyl-amines 5 and 14, useful bifunctional building blocks and of pharmaceutical interest, are synthesized in high enantiomeric purity (e.e. >/= 97 percent).Key step is the diastereoselective 1,2-addition (d.e. 86

Enantioselective Synthesis of Allyl- and Propargylamines via Nucleophilic 1,2-Addition to Chiral Aldimines

The asymmetric synthesis of allylamines and propargylamines 5 in high enantiomeric purity (e.e >/= 97percent) is described.Key step is the 1,2-addition of organocerium reagents to chiral α,β-unsaturated aldimines 3 to produce secondary amines 4.The chiral