147776-97-4Relevant academic research and scientific papers
Heterocycle-Heterocycle Strategy for 4,5-Disubstituted Pyrrolidine 2,3-Diones: Reductive Rearrangement Approach from Isoxazole Esters
Kamath, Prashantha,Jadhav, Vaibhav,Lal, Mukul
supporting information, p. 1146 - 1150 (2021/05/25)
The work demonstrates the heterocycle-heterocycle interconversion strategy to access 4,5-disubstituted 3-hydroxy-2-pyrrolidinone in moderate to good yields (50-80%). The approach has a distinct advantage over a multicomponent reaction approach as it allow
Hypervalent iodine mediated synthesis of di- and tri-substituted isoxazoles via [3+2] cycloaddition of nitrile oxides
Singhal, Ankur,Parumala, Santosh Kumar Reddy,Sharma, Arun,Peddinti, Rama Krishna
supporting information, p. 719 - 722 (2016/02/09)
An efficient and rapid protocol for the synthesis of 3,4-disubstituted and 3,4,5-trisubstituted isoxazoles under catalyst-free conditions is described. This protocol involves pre-oxidation of aldoxime into nitrile oxide using diacetoxyiodobenzene. The in
Efficient synthesis of isoxazoles and isoxazolines from aldoximes using Magtrieve (CrO2)
Bhosale, Sandeep,Kurhade, Santosh,Prasad, Uppuleti Viplava,Palle, Venkata P.,Bhuniya, Debnath
experimental part, p. 3948 - 3951 (2009/10/11)
Treatment of aldoximes 1 with Magtrieve (CrO2) in presence of dipolarophile 3 or 4, furnished a variety of isoxazolines 5a-u and isoxazoles 6a-q as 1,3-dipolar cycloaddition (1,3-DC) products (38 examples; 63-90% isolated yields). In situ formation of a nitrile oxide intermediate was confirmed through isolation of the dimerization product furoxane 2a in absence of any dipolarophile. The methodology has been extended to intramolecular nitrile oxide cycloaddition (INOC) reactions to access highly useful chromane derivatives 7-8 (75-80% isolated yields). Magtrieve, as a new reagent for 1,3-DC reactions, has offered excellent substrate generality and at the same time demonstrated tolerance toward sensitive protecting groups and electron-rich functional groups.
CYCLOADDITION D'OXYDES DE NITRILE A DES DIAZAPHOSPHOLES ET DES COMPOSES APPARENTES. REACTIVITE COMPAREE DES DOUBLES LIAISONS N=C, P=C ET As=C
Yeung Lam Ko, Y. Y. C.,Tonnard, F.,Carrie, R.,Sarlo, F. De,Brandi, A.
, p. 1507 - 1514 (2007/10/02)
Nitrile oxides add to the C=P double bond of 1,2,3-diazaphospholes leading to bicyclic adducts 3 wich are generally unstable, and are easily oxidized. 4-Methyl 2-phenyl 1,2,3-triazole does not react.The corresponding diaza-arsole reacts like the diazaphos
