dimethyl 3-(4-chlorophenyl)-4,5-isoxazoledicarboxylate

Base Information

• Chemical Name: dimethyl 3-(4-chlorophenyl)-4,5-isoxazoledicarboxylate
• CAS No.: 147776-97-4
• Molecular Formula: C₁₃H₁₀ClNO₅
• Molecular Weight: 295.679
• Mol file: 147776-97-4.mol

Synonyms:3-(4-chlorophenyl)isoxazole-4,5-dicarboxylic acid dimethyl ester

Chemical Property of dimethyl 3-(4-chlorophenyl)-4,5-isoxazoledicarboxylate

Chemical Property:

Purity/Quality:

DIMETHYL-3-(4-CHLOROPHENYL)-4,5-ISOXAZOLEDICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 3-(4-chlorophenyl)-4,5-isoxazoledicarboxylate

There total 3 articles about dimethyl 3-(4-chlorophenyl)-4,5-isoxazoledicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl acetylenedicarboxylate (762-42-5) + 4-chlorobenzaldoxime (3848-36-0) → 3-(4-chlorophenyl)isoxazole-4,5-dicarboxylic acid dimethyl ester (147776-97-4)

Guidance literature:

With chromium (VI) oxide; In acetonitrile; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2009.04.073

Reference yield: 76.0%

1-Chloro-4-(chloromethyl)benzene (104-83-6) + dimethyl acetylenedicarboxylate (762-42-5) → 3-(4-chlorophenyl)isoxazole-4,5-dicarboxylic acid dimethyl ester (147776-97-4)

Guidance literature:

1-Chloro-4-(chloromethyl)benzene; With 4-methylmorpholine N-oxide; In acetonitrile; at 80 ℃; for 4h;

With hydroxylamine hydrochloride; potassium carbonate; In acetonitrile; at 20 ℃; for 0.5h;

dimethyl acetylenedicarboxylate; With Oxone; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/ejoc.201701726

Reference yield: 15.0%

3-(4-Chloro-phenyl)-4-methyl-6-phenyl-3a,6-dihydro-[1,2,3]diazarsolo[4,3-d][1,2,5]oxazarsole (82201-27-2) + dimethyl acetylenedicarboxylate (762-42-5) → 3-(4-chlorophenyl)isoxazole-4,5-dicarboxylic acid dimethyl ester (147776-97-4)

Guidance literature:

Ambient temperature;

DOI:10.1016/S0040-4020(01)88555-0

upstream raw materials:

3-(4-Chloro-phenyl)-4-methyl-6-phenyl-3a,6-dihydro-[1,2,3]diazarsolo[4,3-d][1,2,5]oxazarsole

dimethyl acetylenedicarboxylate

4-chlorobenzaldoxime

1-Chloro-4-(chloromethyl)benzene

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