147778-60-7Relevant articles and documents
Enantioselective and diastereoselective formation of syn-3-hydroxy-4-amino acids (syn-statines) via tetramic acids
Schmidt,Riedl,Haas,Griesser,Vetter,Weinbrenner
, p. 216 - 220 (1993)
Enantiomerically pure pyrrolidine-2,4-diones (tetramic acids) which can be diastereoselectively hydrogenated to syn-statines (4-amino-3-hydroxy-6-methylheptanoic acids) have been prepared by catalytic hydrogenation of 4-(benzyloxycarbonylamino)-3-oxocarboxylic acid esters.
AN IMPROVED SYNTHESIS OF β-KETO ESTER UNITS IN DIDEMNINS, USING 2,2'-CARBONYL-BIS(3,5-DIOXO-4-METHYL-1,2,4-OXADIAZOLIDINE).
Jouin, Patrick,Poncet, Joel,Dufour, Marie-Noelle,Maugras, Isabelle,Pantaloni, Antoine,Castro, Bertrand
, p. 2661 - 2664 (2007/10/02)
Activation of N-protected α-amino acids and O-protected α-hydroxy acids with 2,2'-carbonyl-bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) 6 provide a stable activated intermediate 7 suitable for the synthesis of β-keto ester 8.This activation was used in th