14780-23-5Relevant academic research and scientific papers
Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents
Mr?zek, Ond?ej,?ebestová, Lucie,Vinklárek, Jaromír,?ezá?ová, Martina,Eisner, Ale?,R??i?ková, Zdeňka,Honzí?ek, Jan
, p. 519 - 529 (2016)
A series of the cyclopentadienyl and indenyl molybdenum compounds bearing alkylammonium functions [(η5-Cp′)Mo(CO)2(N,NL)][BF4]2 were synthesized and characterized by analytical and spectroscopic methods. The structures of [{η5-C5H4CH2CH2NH(CH2)5}Mo(CO)2(4,7-Ph2-phen)][BF4]2 (4,7-Ph2-phen = 4,7-diphenyl-1,10-phenanthroline) and [(η5-C9H6CH2CH2NHMe2)Mo(CO)2(phen)][BF4]2 (phen = 1,10-phenanthroline) were determined by X-ray crystallography. All of the synthesized compounds exhibit high activity against the human leukemia cell lines MOLT-4 and HL-60. They are approximately one order of magnitude more active than cisplatin. This study has proven that the modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for the design of new highly cytotoxic active species. A series of highly cytotoxic molybdenum(II) complexes are synthesized, and their activity against MOLT-4 and HL-60 leukemia cells is established.
Chiral silicon-bridged 2-(N,N-dialkylamino)ethyl-substituted indenes as potential precursors for ansa-zirconocenes
Hagemeister, Timo,Jutzi, Peter,Stammler, Anja,Stammler, Hans-Georg
, p. 1255 - 1262 (2007/10/03)
Chiral amino-functionalized silicon-bridged indene derivatives 4a-4c were synthesized from 3-(2-(N,N-dialkylamino)ethyl)indenes 2a-2c. The C-Si coupling reactions are regioselective, leading exclusively to the formation of 1,3-disubstituted isomers in a rac/meso ratio of 1:1, as indicated by NMR spectroscopy. The solid-state structure of the dimethylsilyl-bridged bisindene (R,R)-4a is described. The formation of corresponding ansa-zirconocenes via amine elimination chemistry was monitored by 1H NMR spectroscopy.
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands
Boehme, Thomas M.,Keim, Christine,Dannhardt, Gerd,Mutschler, Ernst,Lambrecht, Guenter
, p. 1241 - 1243 (2007/10/03)
In our search for M2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M2-subtype selectivity.
Synthesis and crystal structure of bis(2-dimethylaminoethylindenyl) divalent organolanthanides (Ln=Sm, Yb)
Qian, Changtao,Li, Hengfeng,Sun, Jie,Nie, Wanli
, p. 59 - 62 (2007/10/03)
First examples of racemic bis(2-dimethylaminoethylindenyl) divalent unsolvated organolanthanide complexes (Me2NCH2CH2C9H6) 2Sm (1) and (Me2NCH2CH2C9H6) 2Yb (2) have been synthesized by the reaction of (Me2NCH2CH2C9H6)K with LnI2 (Ln=Sm, Yb). The two compounds have been characterized by elemental analysis and 1H-NMR spectrometry. The X-ray crystal structure of 2 has been determined by diffraction study. The crystals are prismatic, space group P21/a (≠14), with a=17.342(6) A, b=8.542(7) A, c=17.353(2) A, β=118.70°, V=2254(1) A3, Z=4, D=1.607 g cm-3.
