1478097-91-4

Upstream product

• 924-50-5 Methyl 3,3-dimethylacrylate 
• 68641-49-6 bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride 
• 573-97-7 1-bromo-2-naphthol 
• 1477517-11-5 C₁₆H₁₄BrN₂O₆P 
• 178949-51-4 5-Methoxy-7-methyl-naphthalene-1,4-diol 
• 1477517-36-4 C₂₅H₂₉BO₄ 
• 1477517-35-3 C₂₀H₁₇F₃O₅S 
• 1477517-34-2 C₂₄H₂₆O₄ 
• 1477517-33-1 4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl pivalate 
• 65565-56-2 5-methoxy-7-methylnaphthalene-1,4-dione 
• 73311-51-0 1-methoxy-3-methyl-1-trimethylsilyloxy-1,3-butadiene 

Relevant academic research and scientific papers

Efficient syntheses of korupensamines A, B and michellamine B by asymmetric Suzuki-Miyaura coupling reactions

Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a concise and stereoselective synthesis of michellamine B. Chiral monophosphorus ligands L1-3 are effective for the syntheses of a series of functionalized chiral biaryls by asymmetric Suzuki-Miyaura coupling reactions in excellent yields and enantioselectivities (up to 99% ee). The presence of a polar-π interaction between the highly polarized BOP group and the extended π system of arylboronic acid coupling partner is believed to be important for the high enantioselectivity.