1478648-89-3

Upstream product

• 61-54-1 tryptamine 
• 72473-15-5 formyl-4 methoxycarbonyl-2 butanoate de methyle 
• 108-59-8 malonic acid dimethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 1478648-81-5 C₁₈H₂₂N₂O₄ 
• 1478648-84-8 dimethyl 2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate 

Relevant academic research and scientific papers

Synthetic study towards strictamine: The oxidative coupling approach

A synthetic approach featuring a key intramolecular oxidative coupling of a dianion for the formation of the C7-C16 bond was exploited aiming at the synthesis of strictamine. Treatment of substituted tetrahydrocarboline with LHMDS at -78 °C followed by iodine at room temperature afforded a tetracyclic compound, a substructure of eburnane-type alkaloid, via the formation of the Na-C16 bond.

N -Iodosuccinimide-Mediated Oxidative Coupling of Indoles and Phenols: A Synthetic Study toward the Benzofuroindoline Moiety of Bipleiophylline

We report our efforts to apply an N -iodosuccinimide-mediated dearomative oxidative coupling of indoles and phenols to benzofuroindoline-containing polycyclic scaffolds related to the natural product bipleiophylline. Suitable conditions from N-substituted indoles are developed and applied to the synthesis of a hexacyclic model starting from a tetracyclic ABCE precursor.

Palladium-catalyzed heteroannulation approach to 1,2-bis(3-indolyl)ethanes

Palladium-catalyzed heteroannulation between indole-3-butanal and various o-iodoanilines provides a straightforward synthesis of 1,2-bis(3-indolyl) ethanes, which are useful precursors to valued indolo[2,3a]carbazoles. 1,2-Bis(3-indolyl)ethanes bearing a