14788-14-8Relevant articles and documents
Synthesis, IR and NMR studies of zwitterionic ω-(1-pyrrolidine)alkanocarboxylic acids and their N-methyl derivatives
Dega-Szafran, Zofia,Przybylak, Robert
, p. 107 - 121 (1997)
Six ω-(1-pyrrolidine)alkanocarboxylic acid hydrohalides [C4H8N+H(CH2)(n)COOH · X-] and 1-(ω-carboxyalkyl)-1-methyl-pyrrolidinium hydrohalides [C4H8N+CH3(CH2)(n)COOH · X- (n = 1,2,3,4,5,10)] and their sodium and inner salts were synthesized, respectively. IR, 1H and 13C NMR spectra were analyzed with regard to the increasing distance effect on the interaction between the positive nitrogen atom with the negative carboxylic group. The configuration of the pyrrolidine ring was also discussed.
N-heterocyclic propylidene-1,1-bisphosphonic acids, their production and a pharmaceutical composition
-
, (2008/06/13)
The present invention relates to compounds of formula in which R1 -R8 can be the same or different and stand for hydrogen or a straight or branched aliphatic C1 -C10 hydrocarbon radical. In addition, R3 when taken together with either R1 or R5 can form a saturated aliphatic 5-, 6-or 7-membered ring, which may be substituted with one or more C1 -C4 -alkyl radicals. The present compounds are effective e.g. in drugs influencing calcium metabolism.