14788-14-8Relevant academic research and scientific papers
Synthesis, IR and NMR studies of zwitterionic ω-(1-pyrrolidine)alkanocarboxylic acids and their N-methyl derivatives
Dega-Szafran, Zofia,Przybylak, Robert
, p. 107 - 121 (1997)
Six ω-(1-pyrrolidine)alkanocarboxylic acid hydrohalides [C4H8N+H(CH2)(n)COOH · X-] and 1-(ω-carboxyalkyl)-1-methyl-pyrrolidinium hydrohalides [C4H8N+CH3(CH2)(n)COOH · X- (n = 1,2,3,4,5,10)] and their sodium and inner salts were synthesized, respectively. IR, 1H and 13C NMR spectra were analyzed with regard to the increasing distance effect on the interaction between the positive nitrogen atom with the negative carboxylic group. The configuration of the pyrrolidine ring was also discussed.
CEPHALOSPORIN HAVING CATECHOL GROUP
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Page/Page column 57-58, (2011/07/30)
The present invention provides Cephem compounds which have a wide antimicrobial spectrum and have potent antimicrobial activity against beta-lactamase producing Gram negative bacteria as follows: A compound of the formula: wherein, X is N, CH or C-Cl; T is S or the like; A and G are lower alkylene or the like; B is a single bond or the like; D is a single bond, -NR7-, -CO-, -CO-NR7-, -NR7-CO-, -NR7-CO-NR7-, or the like; E is optionally substituted lower alkylene; F is a single bond or optionally substituted phenylene; R3, R4, R5 and R6 each is independently hydrogen, halogene, nitrile, or the like; or an ester, a compound protected at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.
N-heterocyclic propylidene-1,1-bisphosphonic acids, their production and a pharmaceutical composition
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, (2008/06/13)
The present invention relates to compounds of formula in which R1 -R8 can be the same or different and stand for hydrogen or a straight or branched aliphatic C1 -C10 hydrocarbon radical. In addition, R3 when taken together with either R1 or R5 can form a saturated aliphatic 5-, 6-or 7-membered ring, which may be substituted with one or more C1 -C4 -alkyl radicals. The present compounds are effective e.g. in drugs influencing calcium metabolism.
