6317-35-7

Usage

Uses

Used in the Food and Beverage Industry:
Ethyl pyrrolidine-1-propionate is utilized as a flavoring agent to enhance the taste of various food and beverage products. Its slightly sweet taste and safety in small quantities make it a suitable ingredient for this application.
Used in the Pharmaceutical Industry:
In the realm of medicine, ethyl pyrrolidine-1-propionate serves as a key component in the synthesis of pharmaceutical drugs. Its potential medicinal properties contribute to the development of new therapeutic agents, highlighting its importance in drug formulation and innovation.

InChI:InChI=1/C9H17NO2/c1-2-12-9(11)5-8-10-6-3-4-7-10/h2-8H2,1H3

Upstream product

• 123-75-1 pyrrolidine 
• 140-88-5 ethyl acrylate 
• 623-71-2 ethyl 3-chloropropanoate 
• 35247-24-6 ethyl 3-oxo-3-(pyrrolidin-1-yl)propanoate 

Downstream Products

• 6072-22-6 Pyrrinol 
• 13150-56-6 N-(3,3-diphenylallyl)pyrrolidine 
• 111328-90-6 1-(3-hydroxy-3,3-diphenyl-propyl)-1-methyl-pyrrolidinium; iodide 
• 1309863-59-9 N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide 
• 1309863-60-2 N'-{2-[(4-chloro-2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide 
• 1309863-61-3 N'-{2-[(4-methoxy-2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide 
• 76234-38-3 β-(1-Pyrrolidinyl)-Propionic Acid 
• 14788-14-8 3-(pyrrolidin-1-yl)propanoic acid hydrochloride 
• 77-37-2 procyclidine 

Relevant academic research and scientific papers

Ir-catalyzed chemoselective reduction of β-amido esters: A versatile approach to β-enamino esters

The conversion of β-amido esters to β-enamino esters is an indispensable step for some synthetic approaches to alkaloids and related medicines. Known methods for such transformation are not only stepwise, but also proceed with low atom-efficiency. Herein, we report a direct and versatile approach that features the Ir-catalyzed chemoselective reduction of β-amido esters with 1,1,3,3-tetramethyldisiloxane (TMDS). In addition, a lack of some signals was observed in the 13C NMR spectra of some alicyclic β-enamino esters. This revealed a longstanding existing but being ignored phenomenon in the literature.

Nickel(II) N-Heterocyclic Carbene Complexes: Versatile Catalysts for C–C, C–S and C–N Coupling Reactions

A variety of NiII complexes with a wide range of electronic and steric properties, bearing picolylimidazolidene ligands (a–g) and Cp (Cp = η5-C5H5; 2a–f) or Cp* (Cp* = η5-C5Me5; 3a, c, g) groups, have been synthesised and characterised by using NMR spectroscopy and single-crystal X-ray crystallography. The complexes have been used as precatalysts for a wide range of catalytic transformations, which most likely involve a Ni0/NiII catalytic cycle. In particular, the new well-defined 2a, 2c, 3a and 3c complexes have demonstrated great efficiency and versatility towards Suzuki–Miyaura coupling reactions, hydroamination of activated olefins and C–S cross-coupling reactions of aryl halides and thiols under mild conditions.

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl) acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide.

Bromodimethylsulfonium bromide mediated Michael addition of amines to electron deficient alkenes

Bromodimethylsulfonium bromide has been found to be an efficient catalyst for the Michael addition of a wide variety of amines to electron deficient alkenes at room temperature. The protocol is very simple and chemoselective. Aliphatic and benzylic amines undergo conjugate addition within a very short period under solvent-free conditions and provide excellent yields of products.

Samarium(III) triflate catalyzed conjugate addition of amines to electron-deficient alkenes

Amines undergo smooth nucleophilic addition to α,β-unsaturated compounds in the presence of a catalytic amount of samarium(III) triflate at ambient temperature to produce the corresponding β-amino compounds in excellent yields. This method is simple, convenient, and works efficiently under mild conditions. Georg Thieme Verlag Stuttgart.

Cadmium chloride (CdCl2): An efficient catalyst for conjugate addition of amines to electron-poor alkenes

Electron-deficient olefins undergo rapid Aza-Michael reaction with a wide range of amines catalyzed by cadmium chloride at room temperature. Copyright Taylor & Francis Group, LLC.

Zirconium(IV) chloride-mediated chemoselective conjugate addition of aliphatic amines to α,β-ethylenic compounds

Zirconium chloride efficiently catalyzes the conjugate addition of a variety of aliphatic amines to α,β-unsaturated ester, nitriles, and ketones to give the corresponding β-amino derivatives in excellent yields under mild reaction conditions. Aromatic amines do not participate in this transformation. Copyright Taylor & Francis Group, LLC.

Synthesis of β-amino esters via aza-Michael addition of amines to alkenes promoted on silica: A useful and recyclable surface

A solvent-free protocol for the synthesis of β-amino esters and nitriles has been developed via conjugate addition of amines to electron-deficient alkenes promoted on silica. The silica surface may be recycled. Both aliphatic and aromatic primary or secondary amines worked efficiently to yield the desired adducts in good to excellent yields.

Rhodium(II) acetate catalyzed synthesis of cyclic enamides and enamines via β-hydride elimination

A series of cylic diazoamides and diazoamines were synthesized. Treatment of these cylic diazoamides and diazoamines with a catalytic amount of rhodium(II) acetate furnished the corresponding cyclic enamides and enamines, respectively. Interestingly, cyclic diazoamines produced stereoselectively Z-enamines.

CATALYSIS OF THE SPECIFIC MICHAEL ADDITION : THE EXAMPLE OF ACRYLATE ACCEPTORS

Lewis acids, ferric chloride in particular, catalyze the addition of amine nucleophiles to arcylates.Yields are very good, under mild conditions.Exlusive 1,4-addition occurs, and polymerization is avoided.