14794-06-0

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 4-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)BENZOATE is used as a building block for the synthesis of pharmaceutical compounds due to its chemical structure and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used as an Antibacterial Agent:
In the field of microbiology and pharmaceuticals, ETHYL 4-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)BENZOATE is studied for its potential as an antibacterial agent, indicating its capacity to combat bacterial infections and contribute to the discovery of new antimicrobial substances.
Used for Anti-Inflammatory and Analgesic Properties:
ETHYL 4-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)BENZOATE is also being investigated for its anti-inflammatory and analgesic properties, suggesting its potential use in the treatment of conditions characterized by inflammation and pain, thereby enhancing the range of therapeutic options available for such ailments.

InChI:InChI=1/C13H11NO4/c1-2-18-13(17)9-3-5-10(6-4-9)14-11(15)7-8-12(14)16/h3-8H,2H2,1H3

Upstream product

• 94-09-7 p-aminoethylbenzoate 
• 53616-17-4 ethyl 4-[[(2Z)-3-carboxy-1-oxo-2-propen-1-yl]amino]benzoate 

Downstream Products

• 871497-00-6 C₂₂H₂₁N₅O₆S₂ 
• 868155-16-2 C₁₇H₁₇N₅O₅S₂ 
• 868155-13-9 C₁₇H₁₇N₅O₅S₂ 
• 1170853-48-1 ethyl 4-(5-oxo-3-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-7-carboxamido)benzoate 
• 1305287-24-4 ethyl 4-(3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridine-4-carboxamido)benzoate 

Relevant academic research and scientific papers

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita

Different maleimide derivatives were synthesized and assayed for their in vitro activity on the soil inhabiting, plant-parasitic nematode Meloidogyne incognita, also known as root-knot nematode. The compounds maleimide, N-ethylmaleimide, N-isopropylmaleimide, and N-isobutylmaleimide showed the strongest nematicidal activity on the second stage juveniles of the root-knot nematode with EC50/72h values of 2.6 ± 1.3, 5.1 ± 3.4, 16.2 ± 5.4, and 19.0 ± 9.0 mg/L, respectively. We also determined the nematicidal activity of copper sulfate, finding an EC50 value of 48.6 ± 29.8 mg/L. When maleimide at 1 mg/L was tested in combination with copper sulfate at 50 mg/L, we observed 100% mortality of the nematodes. We performed a GC-MS metabolomics analysis after treating nematodes with maleimide at 8 mg/L for 24 h. This analysis revealed altered fatty acids and diglyceride metabolites such as oleic acid, palmitic acid, and 1-monopalmitin. Our results suggest that maleimide may be used as a new interesting building block for developing new nematicides in combination with copper salts.

4-(3-Dialkylamino-2,5-dioxopyrrolidin-1-yl)benzoic acid esters

Reactions of alkyl 4-aminobenzoates with maleic anhydride give the corresponding alkyl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoates, and the latter are converted into 4-(3-dialkylamino-2,5-dioxo-2,3,4,5-tetrahydro-1H- pyrrol-1-yl)benzoates by treatme