147986-46-7

Upstream product

• 147986-42-3 (S)-4-Bromo-3-hydroxy-4-pentenoic acid (S)-1,2,2-triphenyl-2-hydroxyethyl ester 
• 148023-09-0 (S)-4-Bromo-3-(tert-butyl-dimethyl-silanyloxy)-pent-4-enal 
• 147986-44-5 (S)-4-Bromo-3-<(tert-butyldimethylsilyl)oxy>-4-penten-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 147986-45-6 (3S,5S)-6-Bromo-5<(tert-butyldimethylsilyl)oxy>-3-hydroxy-6-heptenoic acid (R)-1,2,2-triphenyl-2-hydroxyethyl ester 

Downstream Products

• 129482-80-0 methyl (Z,3S,5R)-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]acetate 

Relevant academic research and scientific papers

An Efficient Asymmetric Synthesis of 1α,25-(OH)2 Vitamin D3 A-Ring Synthon

Chiral synthesis of the A-ring synthon 3 of 1α,25-dihydroxyvitamin D3 (1a) based on palladium-catalyzed cyclization of 8-bromo-2,8-nonadienoates is described.Reaction of (E)-4b and (Z)-4d in the presence of Pd(OAc)2, PPh3 and K2CO3 gave (E)-3b and (Z)-3d, respectively.Optically active 4d was prepared from 24 by asymmetric aldol reaction using 31, which was cyclized to 3d.With further reactions, 1α,25-dihydroxyvitamin D3 (1a) was obtained.