147986-42-3Relevant academic research and scientific papers
An Efficient Asymmetric Synthesis of 1α,25-(OH)2 Vitamin D3 A-Ring Synthon
Nagasawa, Kazuo,Ishihara, Hideki,Zako, Yoshiro,Shimizu, Isao
, p. 2523 - 2529 (1993)
Chiral synthesis of the A-ring synthon 3 of 1α,25-dihydroxyvitamin D3 (1a) based on palladium-catalyzed cyclization of 8-bromo-2,8-nonadienoates is described.Reaction of (E)-4b and (Z)-4d in the presence of Pd(OAc)2, PPh3 and K2CO3 gave (E)-3b and (Z)-3d, respectively.Optically active 4d was prepared from 24 by asymmetric aldol reaction using 31, which was cyclized to 3d.With further reactions, 1α,25-dihydroxyvitamin D3 (1a) was obtained.
