1479965-70-2Relevant academic research and scientific papers
Design and evaluation of 3-(benzylthio)benzamide derivatives as potent and selective SIRT2 inhibitors
Khanfar, Mohammad A.,Quinti, Luisa,Wang, Hua,Nobles, Johnathan,Kazantsev, Aleksey G.,Silverman, Richard B.
supporting information, p. 607 - 611 (2015/05/27)
Inhibitors of sirtuin-2 (SIRT2) deacetylase have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology. The present study was directed at optimizing the potency of SI
BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE
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Paragraph 0084; 0253, (2014/07/08)
Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
