148014-93-1

Upstream product

• 148014-96-4 5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-6-nitrobenzimidazole 
• 7440-66-6 zinc 
• 89-61-2 2,5-dichloronitrobenzene 
• 148014-95-3 5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole 
• 148014-94-2 2,5-dichloro-1-isopropylbenzimidazole 
• 89659-68-7 5-chloro-2-<(1-methylethyl)amino>aniline 
• 89659-82-5 5-chloro-1,3-dihydro-1-(1-methylethyl)-2H-benzimidazol-2-one 
• 89659-66-5 4-chloro-N-isopropyl-2-nitrobenzenamine 
• 109-01-3 1-methyl-piperazine 

Relevant academic research and scientific papers

Benzimidazole derivative, process for preparing the same, antiemetic agent containing the same as active ingredient and intermediate compound for preparing the same

A benzimidazole derivative having the following formula (I): STR1 or a pharmaceutically acceptable acid addition salt thereof, a process for preparing the same, an antiemetic agent containing the same as an active ingredient and an intermediate compound for preparing the same. The above novel benzimidazole derivative has a continuous 5-HT3 antagonistic activity, shows preventive and therapeutic effects against vomiting caused by cisplatin and has a low toxicity, and hence, is useful as an antiemetic agent against vomiting due to chemotherapeutic treatment with cisplatin etc.

Design and syntheses of a series of novel serotonin3 antagonists

From a structural comparison study between serotonin and serotonin3 (5- HT3) antagonists using a two-dimensional grid template composed of regular hexagons, we deduced structural modification patterns from agonists to antagonists, an